Chased out of the old world, the dark vampire lord Giovanni flees to the American southwest where he sets up a new brood. Longshank, Brittan's premier vampire slayer follows him here, and in a final confrontation in the Arizona desert both are killed. A hundred years later Melissa, a gorgeous, goth, lesbian college student, is obsessed with becoming a vampire and escaping her terrible home life. Along with her four friends, Ted, Liz, Mona, and Kent, she regularly conducts ceremonies where she tries to commune with dark forces. When she buys an old, evil book at a creepy garage sale she finally has the key she has been searching for. Following her dreams of Giovanni and a map in the book the five friends hike out to "Massacre Lane" and finally summon up some real vampires.

清末明初，故事发生在中国西部大戈壁黄沙镇。剧情以除暴安民为线索，主人公王笑天、花儿红与恶霸、官府间展开了一场殊死的博斗，描述了主人公悲欢离合，生死离别的坎坷命运。

敌后武工队在沙河境内面临两大劲敌，一是日本侵略军，二是落草为寇的国民党旧部某团，在日军的扫荡中，武工队李队长为救国军旧部的刘团长险些丧命，从此二人结为兄弟，刘团长成功加入共产党，共同歼灭沙河境内日军……